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LIVVON DIABEGARD 60T

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: 0116311

: New

MAL20020739TC

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RM46.50

RM58.30

-RM11.80

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A UNIQUE ROUTE OF ABSORBTION 
Sublingual literally means 'under the tongue'. It is a method of administering substances by placing the medication under the tongue to gain rapid and direct entry into the blood vessels rather than via the digestive tract. Medically, sublingual drug administration is applied in the field of cardiovascular drugs.
Why is Polypeptide-k® sublingually administered?
This route is often faster, and entering polypeptide-k ® into one's body sublingually ensures that the protein will not come in contact with the incredibly hostile environment of the gastrointestinal tract where a much greater percentage of the original substance is degraded either by a stew of enzymes or the strong acids in the GI tract. Additionally after GI absorption, the protein is sent to the liver where it may be further extensively metabolized.
 
The principle behind sublingual administration
When polypeptide-k ®  comes in contact with the mucous membrane, or buccal mucosa, it diffuses into the epithelium beneath the tongue, the sublingual areas act like a blotting paper, readily soaking up the substance. This region contains a high density of blood vessels, and as a result, via osmosis, the substance quickly enters the blood stream at the sublingual artery and thereafter, polypeptide-k ® is carried by blood flow to the connected lingual artery.
 
Can all substances be administered sublingually?
Not all substances are permeable and accessible to the buccal mucosa. In order for a nutrient to be effectively absorbed sublingually, it needs to be able to travel accross the buccal mucous membranes; by a process of diffusion known as osmosis and factors, such as pH, molecular weight, and lipid solubility of a substance may determine whether the route is possible.

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